1. Inhalt (Content): Introduction: Building principles of biological macromelecules, dynamics of biomolecules Theoretical basis: Interactions of molecules, statistical mechanics, equation of motion Special techniques and applications: Saving CPU-time, energy minimization, normal modes, computation of electrostatic energies, computation of free energies. 2. Literatur: Andrew Leach, Molecular Modeling, Principles and Applications Wesley Longman 1996. 3. Remarks: The lecture is suitable for students of biochemistry, chemistry, physics and mathematics after the bachelor. It provides an introduction and is required to attend the two-week exercise 21 541 b with work stations. It yields the theoretical basis for modeling and computer simulation of biological macromolecules. Schließen