216501b

SoSe 18: Membrane Proteins: Classification, Structure and Function / Seminar zur Vorlesung Membranproteine: Klassifizierung, Struktur und Funktion

Stefan Kubick

Hinweise für Studierende

Muss zusammen mit V 216501a besucht werden.
Ist Voraussetzung für das S/P 216451 a, b

Kommentar

Inhalt / Content:
Intended for graduate students, this seminar will introduce the tools of membrane protein synthesis and their functional characterization. Membrane proteins account for more than 30% of the genome in living organisms and many membrane-embedded receptors, transporters and ion channels are important therapeutic targets. In this context, methodologies concerning the functional characterization, the structure and the biochemical properties of membrane proteins, their regulation and their physiological relevance are in the focus of this seminar. Emphasis is given to topics that will be useful in other disciplines, including systems for the in vivo and in vitro expression of membrane proteins. The seminar gives a detailed introduction on problems concerning the interaction of chemical messengers with specific cell-surface receptors, the activation of signal-transduction cascades leading to the accumulation of specific intracellular second messenger molecules and the cell’s response to an external stimulus. Beside others the following topics are discussed in detail: Ligand-gated ion channels and their signaling between electrically excitable cells; G protein-coupled receptors, triggering downstream signal transduction cascades, thereby activating separate membrane-associated enzymes and catalytic receptors, acting as enzymes themselves. A critical approach to lipid-membrane protein interactions and the pharmacological properties of selected membrane proteins is also in the focus of this seminar.

Zeitgleiche Durchführung zur o.g. Vorlesung, detaillierte Beschreibung siehe Vorlesung.

Dr. S. Kubick: stefan.kubick@izi-bb.fraunhofer.de
Fraunhofer Institut für Zelltherapie und Immunologie (IZI), Institutsteil Bioanalytik und Bioprozesse(IZI-BB) Potsdam-Golm, Am Mühlenberg 13, 14476 Potsdam Schließen