216641a
Seminar
SoSe 18: Molekulare und zelluläre Grundlagen neurodegenerativer Proteinaggregationskrankheiten wie Morbus Alzheimer, Parkinson-Krankheit und Prionerkrankungen / Molecular and cellular basis of neurodegenerative proteopathies.
Michael Beekes
Information for students
Der Besuch des Seminars ist Voraussetzung für eine Teilnahme am Praktikum mit Seminar "Selbstreplizierende Proteinpartikel und Neurodegeneration bei Morbus Alzheimer, Parkinson-Krankheit und Prionerkrankungen" (216641b, c) im WS . close
Comments
Content:
PD Dr. M. Beekes: BeekesM@rki.de close
- Cerebral proteopathies: Alzheimer´s disease, Parkinson´s disease, prion diseases
- Portrait of the diseases
- Protein aggregation as a common molecular key feature of different proteopathies
- Nucleation-dependent protein polymerization of amyloid-beta (Aß) and tau protein, alpha-synuclein and prion protein in Alzheimer´s, Parkinson´s and prion diseases, respectively
- Amyloid fibril formation
- Structure models and polymorphisms of amyloid fibrils
- Transmissibility of protein seeding and disease features by self-replicating Aß-, tau-, a-syn- and PrP particles
- Pathophysiology, diagnostics and therapy
PD Dr. M. Beekes: BeekesM@rki.de close