216501b

SoSe 20: Membrane Proteins: Classification, Structure and Function

Stefan Kubick

Information for students

powerpoint with voice-over and/or videoconference at the regular tiime,
(Start: Dienstag, 21.4., Anmeldung zur Vorlesung per email an: Stefan.kubick@izi-bb.fraunhofer.de)
Classes 216501 a and b must be attended together. Their succesfull completion is obligatory for the application for the method module 216451 a, b! close

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Inhalt / Content:
Intended for graduate students, this seminar will introduce the tools of membrane protein synthesis and their functional characterization. Membrane proteins account for more than 30% of the genome in living organisms and many membrane-embedded receptors, transporters and ion channels are important therapeutic targets. In this context, methodologies concerning the functional characterization, the structure and the biochemical properties of membrane proteins, their regulation and their physiological relevance are in the focus of this seminar. Emphasis is given to topics that will be useful in other disciplines, including systems for the in vivo and in vitro expression of membrane proteins. The seminar gives a detailed introduction on problems concerning the interaction of chemical messengers with specific cell-surface receptors, the activation of signal-transduction cascades leading to the accumulation of specific intracellular second messenger molecules and the cell’s response to an external stimulus. Beside others the following topics are discussed in detail: Ligand-gated ion channels and their signaling between electrically excitable cells; G protein-coupled receptors, triggering downstream signal transduction cascades, thereby activating separate membrane-associated enzymes and catalytic receptors, acting as enzymes themselves. A critical approach to lipid-membrane protein interactions and the pharmacological properties of selected membrane proteins is also in the focus of this seminar.

Seminar takes place right after the lecture (s. above)

Dr. S. Kubick: stefan.kubick@izi-bb.fraunhofer.de
Fraunhofer Institut für Zelltherapie und Immunologie (IZI), Institutsteil Bioanalytik und Bioprozesse(IZI-BB) Potsdam-Golm, Am Mühlenberg 13, 14476 Potsdam close