SoSe 21: Advanced Biophysics
Stephan Block
Comments
Inhalt: 10 ECTS; only together with practical course 20114102!
This module will present and substantiate biophysical methods and concepts. Selected methods like spectroscopy and diffraction and their application to proteins and biomembranes are of particular relevance. The lecture series will cover a selection of the following methods:
absorption spectroscopy in the UV, visible and IR region;
fluorescence spectroscopy,
time-resolved approaches;
spectroscopy with polarized light;
vibrational spectroscopy: Fourier-transform infrared (FTIR), resonance Raman, surfance-enhanced Raman and IR;
diffraction with X-rays, Neutrons and electrons;
crystallization and protein crystallography;
nuclear magnetic resonance (NMR); light scattering; single molecule spectroscopy;
atomic force microscopy (AFM and optical tweezer);
theoretical methods: MD simulations, Poisson-Boltzmann, QM/MM, coarse-grained MD
closeSuggested reading
Since a comprehensive textbook in Biophysics is not available, here is a list of books from which parts will be used in the lecture:
Sackmann & Merkel: Lehrbuch der Biophysik
Tuszynski & Kurzynski: Introduction to Molecular Biophysics.
Cantor & Schimmel: Biophysical Chemistry.
Walla: Modern Biophysical Chemistry.
Brandén & Tooze: Introduction to Protein Structure.
Winter & Noll: Methoden der Biophysikalischen Chemie.
Gennis: Biomembranes
close28 Class schedule
Regular appointments