Enrollment via mail to: BeekesM@rki.de until 31.07.21.
ATTENTION: Attendance of this seminar is a prerequisite for participation in the lab course with seminar "Self-replicating protein particles and neurodegeneration in Alzheimer's disease, Parkinson's disease and prion diseases" (216641b, c) in the winter semester. close

Content:

• Cerebral proteopathies: Alzheimer´s disease, Parkinson´s disease, prion diseases
• Portrait of the diseases
• Protein aggregation as a common molecular key feature of different proteopathies
• Nucleation-dependent protein polymerization of amyloid-beta (Aß) and tau protein,
alpha-synuclein and prion protein in Alzheimer´s, Parkinson´s and prion diseases, respectively
• Amyloid fibril formation
• Structure models and polymorphisms of amyloid fibrils
• Transmissibility of protein seeding and disease features by self-replicating Aß-, tau-, a-syn- and PrP particles
• Pathophysiology, diagnostics and therapy

PD Dr. M. Beekes: BeekesM@rki.de close