216641a Seminar

SoSe 22: Molecular and cellular basis of neurodegenerative proteopathies.

Michael Beekes

Information for students


ATTENTION: Attendance of this seminar is a prerequisite for participation in the lab course with seminar "Self-replicating protein particles and neurodegeneration in Alzheimer's disease, Parkinson's disease and prion diseases" (216641b, c) in the winter semester. close

Comments

Content:
  • Cerebral proteopathies: Alzheimer´s disease, Parkinson´s disease, prion diseases
  • Portrait of the diseases
  • Protein aggregation as a common molecular key feature of different proteopathies
  • Nucleation-dependent protein polymerization of amyloid-beta (Aß) and tau protein,
  • alpha-synuclein and prion protein in Alzheimer´s, Parkinson´s and prion diseases, respectively
  • Amyloid fibril formation
  • Structure models and polymorphisms of amyloid fibrils
  • Transmissibility of protein seeding and disease features by self-replicating Aß-, tau-, a-syn- and PrP particles
  • Pathophysiology, diagnostics and therapy


PD Dr. M. Beekes: BeekesM@rki.de close

Subjects A - Z